A premise of unknowing is that, while not knowing is a defining condition of life, we mostly behave as if we know.
At its most basic level, our not knowing is a truism. While each of us functions from our own individual base of knowledge, an inescapable facet of existence is that we do not know what the future holds. Perhaps not even the next moment. Much of our knowing is nothing more than pattern recognition. We hold a rough model in our heads of what reality is like and this is good enough to enable us to function efficiently most of the time.
But this pattern recognition can blind us to the novelty we navigate every day of our lives. Even when we encounter situations that seem similar to ones we have seen before, we tend to forget that each unfolding of a familiar event is unique in its own right. Our knowing forms amid a broader canvas of not knowing.